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Submitted: 05 Mar 2022
Accepted: 02 Jan 2023
ePublished: 22 Jan 2023
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J Renal Inj Prev. 2023;12(1): e32040.
doi: 10.34172/jrip.2023.32040
  Abstract View: 72
  PDF Download: 46

Review

Potential biomarkers of chronic kidney disease progression among kidney-derived proteins; a review

Sangeetha Prabhu Kademani 1 ORCID logo, Prabhudas Nelaturi 1 ORCID logo, Vishnu Bhat 2 ORCID logo, Sathya Sagar 3 ORCID logo, Ravikumar Sambandam 1* ORCID logo

1 Multi-Disciplinary Centre for Biomedical Research, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Puducherry, India
2 Director - Medical Research, Professor of Pediatrics and Neonatology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Puducherry, India
3 Division of Nephrology, Department of General Medicine, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Puducherry, India
*Corresponding Author: Corresponding author: Ravikumar Sambandam, Email: , Email: ravikumar.sambandam@avmc.edu.in

Abstract

The incidence and mortality rate of kidney disease and its progression to end-stage disease have predominantly increased worldwide. Other morbid conditions, such as diabetes and hypertension, are major risk factors for kidney disease. Detection of kidney disease is difficult due to its heterogeneity and complex pathophysiology. Kidney injury and advanced stages of the disease are currently assessed by traditional biomarkers such as serum creatinine, albuminuria, proteinuria and estimated glomerular filtration rate. Numerous biomarkers derived from the kidney involved in endothelial dysfunction, inflammatory processes and tubular cell damage are potential targets for disease progression management. The review summarized potential biomarkers of chronic kidney disease (CKD) to improve patient care in various clinical practices with an increased focus on loss of kidney function.

Implication for health policy/practice/research/medical education:

Acquiring knowledge regarding potential noninvasive biomarkers of kidney-derived proteins in the progression of CKD may provide information that will aid in the development of novel therapeutics to improve the clinical outcomes and quality of life of individuals with kidney disease.

Please cite this paper as: Kademani SP, Nelaturi P, Bhat V, Sagar S, Sambandam R. Potential biomarkers of chronic kidney disease progression among kidney-derived proteins; a review. J Renal Inj Prev. 2023; 12(1): e32040. doi: 10.34172/jrip.2023.32040.

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