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Submitted: 05 Apr 2023
Accepted: 08 Jun 2023
ePublished: 04 Jul 2023
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J Renal Inj Prev. 2024;13(2): e32195.
doi: 10.34172/jrip.2023.32195
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  PDF Download: 298

Review

Prevalence and predicting factors of acute kidney injury due to methanol intoxication; a systematic review

Mohammad Hesam Gharaeikhezri 1 ORCID logo, Farinaz Fattahi 2 ORCID logo, Pegah Karami 3 ORCID logo, Arash Izadpanah Ghahremani 4 ORCID logo, Bareza Rezaei 5 ORCID logo, Hooman Rafiei 5 ORCID logo, Hamidreza Khodabandeh 6 ORCID logo, Aisan Ghasemi Oskui 7 ORCID logo, Farshad Gharebakhshi 6 ORCID logo, Mohammad Reza Rezaei 5* ORCID logo

1 School of Medicine, Islamic Azad University of Yazd, Yazd, Iran
2 Department of Emergency Medicine, School of Medicine, Milad Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of General Medicine, Borkhar-o-Meymeh Health and Treatment, School of Medicine, Isfahan University of Medical Sciences, Shahin-Shahr, Iran
4 Department of Emergency Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran
5 Department of Emergency Medicine, Taleghani and Imam Reza Hospitals, School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran
6 Department of Radiology, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Department of Emergency Medicine, Clinical Research Development Center of Taleghani and Imam Reza Hospitals, School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran
*Corresponding Author: Mohammad Reza Rezaei, Email: mohammadreza.rezaei@kums.ac.ir

Abstract

Introduction: Methanol intoxication and subsequence acute kidney injury (AKI) can be dangerous and deadly in case of a missed or delayed diagnosis; therefore, identifying its prevalence and predictor factors is necessary.

Objectives: This study was conducted to identify the prevalence and predictor factors of AKI in methyl alcohol-intoxicated patients.

Methods and Materials: The search strategy was conducted with the standard keyword in the international database, including Web of Science, Scopus, PubMed /Medline, Embase, Cochrane, WorldCat, Dimension, OpenGrey, EBSCO, DOAJ, CINAHL, and Google scholar search engines. Studies that reported the prevalence of AKI due to methanol poisoning were included in this review study.

Results: Results demonstrated that six studies from five countries, with a sample size of 816 methanol intoxication patients, were included in this study. Mean AKI prevalence in all reviewed studies was 28.18%; Gender male, hypertension, older age, anemia, alcohol addiction, metabolic acidosis, high blood osmolality, high Formate concentration, alcohol overdose, sepsis, rhabdomyolysis, acute pancreatitis, and volume depletion were the reported AKI predictors in the reviewed studies.

Conclusion: Identifying the AKI prevalence and its predictor factors in patients with methanol intoxication can help in their quick diagnosis, timely treatment, and reduce the subsequent complications.


Implication for health policy/practice/research/medical education:

In a systematic review of studies that evaluated the prevalence and related factors to progressed AKI due to methanol poisoning, we found that its prevalence was 28.18%; demographic characteristics, including older age, gender male, hypertension, anemia, history of alcohol consumption, and clinical findings such as high blood osmolality, greater pH, acute pancreatitis, alcohol overdose, sepsis, rhabdomyolysis, and volume depletion were the most common predictors for incidence of AKI.

Please cite this paper as: Gharaeikhezri MH, Fattahi F, Karami P, Izadpanah Ghahremani A, Rezaei B, Rafiei H, Khodabandeh H, Ghasemi Oskui A, Gharebakhshi F, Rezaei MR. Prevalence and predicting factors of acute kidney injury due to methanol intoxication; a systematic review. J Renal Inj Prev. 2024; 13(2): e32195. doi: 10.34172/jrip.2023.32195.

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