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Submitted: 30 Aug 2023
Accepted: 11 Nov 2023
ePublished: 04 Dec 2023
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J Renal Inj Prev. 2024;13(1): e32227.
doi: 10.34172/jrip.2023.32227
  Abstract View: 503
  PDF Download: 257

Original

The correlation between serum fibroblast growth factor-23 levels and left ventricular hypertrophy in chronic kidney disease patients

Abdul Mubdi AA Karim 1* ORCID logo, Hasyim Kasim 2 ORCID logo, Akhyar Albaar 2 ORCID logo, Sitti Rabiul Zatalia Ramadhan 2 ORCID logo, Nasrum Machmud 2, Haerani Rasyid 2 ORCID logo, Pendrik Tandean 3 ORCID logo, Syakib Bakri 2 ORCID logo, Erwin Arief 4 ORCID logo, Tutik Harjianti 5 ORCID logo, Risna Halim 6 ORCID logo, Arifin Seweng 7 ORCID logo

1 Department of Internal Medicine, Universitas Muslim Indonesia, Makassar, Indonesia
2 Nephrology and Hypertension Division, Department of Internal Medicine, Hasanuddin University, Makassar, Indonesia
3 Cardiovascular Division, Department of Internal Medicine, Hasanuddin University, Makassar, Indonesia
4 Pulmonary and Intensive Care Division, Department of Internal Medicine, Hasanuddin University, Makassar, Indonesia
5 Hematology and Oncology Division, Department of Internal Medicine, Hasanuddin University, Makassar, Indonesia
6 Tropical Infection Division, Department of Internal Medicine, Hasanuddin University, Makassar, Indonesia
7 Department of Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
*Corresponding Author: Abdul Mubdi AA Karim, Email: abdulmubdiardiansararifuddin.karim@umi.ac.id, Email: abdul.mubdi125@gmail.com

Abstract

Introduction: Hyperphosphatemia in chronic kidney disease (CKD) patients can stimulate the production of the fibroblast growth factor-23 (FGF-23) phosphatonin hormone, which is associated with cardiac remodeling resulting in left ventricular hypertrophy (LVH).

Objectives: To determine the correlation between FGF-23 level and LVH incidence in CKD patients and establish the associated risk factors.

Materials and Methods: This cross-sectional study involved 74 CKD patients who were classified as stage 3 (n=18), stage 4 (n=17), stage 3 (n=18), dialysis stage 5 (n=20), or non-dialysis stage 5 (n=19). The FGF-23 levels of the patients were measured using the ELISA (enzyme-linked immunosorbent assay) kit method, whereas a cardiologist verified LVH using an echocardiographic examination based on the LVH criteria of >95 g/m2 for females and >115 g/m2 for males.

Results: A significant difference was observed in the mean FGF-23 values between the LVH and non-LVH patients (443.27±437.047 RU/mL and 172.68±185.56 RU/mL, respectively; P<0.05). The receiver operating characteristics revealed that patients with FGF-23 levels >123.95 RU/mL had a 3.6 times greater risk of LVH compared to those with values ≤123.95 RU/mL. The LVH risk factors of gender and age, as well as hypertension, diabetes mellitus, and obesity diagnoses were not associated with LVH incidence in CKD patients.

Conclusion: A significant association was found between FGF-23 level and LVH incidence in CKD patients, in which an FGF-23 level >123.95 RU/mL corresponded to a 3.6 times greater risk of LVH than those with FGF-23 levels below this value.


Implication for health policy/practice/research/medical education:

Hyperphosphatemia can occur in patients with chronic kidney disease and this leads to the stimulation of the FGF-23 phosphatonin hormone. This hormone is associated with cardiac remodeling that results in LVH. A significant association was found between FGF-23 level and LVH incidence in CKD patients, whereby FGF-23 levels >123.95 RU/mL were associated with a 3.6 times higher risk of LVH compared to patients with levels ≤ 123.95 RU/mL.

Please cite this paper as: Karim AMAA, Kasim H, Albaar A, Zatalia Ramadhan SR, Machmud N, Rasyid H, Tandean P, Bakri S, Arief E, Harjianti T, Halim R, Seweng A. The correlation between serum fibroblast growth factor-23 levels and left ventricular hypertrophy in chronic kidney disease patients. J Renal Inj Prev. 2024; x(x): e32227. doi: 10.34172/jrip.2023.32227.

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