Logo-jrip
Submitted: 13 Apr 2023
Accepted: 10 Sep 2023
ePublished: 02 Oct 2023
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Renal Inj Prev. 2023;12(4): e32240.
doi: 10.34172/jrip.2023.32240

Scopus ID: 85174674320
  Abstract View: 1492
  PDF Download: 935

Clinical Trial

The effects of Portulaca oleracea extract on 24-hour urine indices in patients with renal stone: A double-blind randomized placebo-controlled clinical trial

Amirhesam Alirezaei 1 ORCID logo, Kimia Karimi Toudeshki 2 ORCID logo, Seyed Behnaz Nouri 3 ORCID logo, Seyed Amirhossein Fazeli 4 ORCID logo, Firoze Hatami 5 ORCID logo, Amirhossein Miladipour 6 ORCID logo, Seyed Pedram Montazeri-Ghominezhad 7* ORCID logo

1 Clinical Research and Development Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Cardiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4 Clinical Research and Development Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Chronic Kidney Disease Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Department of Internal Medicine, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Seyed Pedram Montazeri-Ghominezhad, Email: Montazeri.pedram@yahoo.com

Abstract

Introduction: Portulaca oleracea, or purslane, is a medicinal plant used in traditional medicine, according to its various medical properties, as well as its potential antioxidant and anti-inflammatory properties.

Objectives: The present study aimed to investigate the efficacy of P. oleracea powder on 24-hour urine indices in patients with nephrolithiasis and normal kidney function.

Patients and Methods: In this randomized clinical trial, eligible patients with nephrolithiasis were randomly assigned to receive P. oleracea or placebo capsules once daily for eight weeks. Twenty-four-hour urine indices, along with serum electrolytes, inflammatory and lipid components were measured, then compared between the two groups at baseline and the end of the trial.

Results: A total of 54 patients, including 28 in P. oleracea and 26 in the control groups, were assigned. Their mean age was 42.2±9.8 years; there was no statistically significant difference between the mean age of the P. oleracea and placebo groups (42.1years versus 42.2 years, respectively; P>0.05). After eight weeks, the mean urine citrate level in the Portulaca oleracea subjects (674.82±94.56 mg/24 h) was significantly higher than placebo group subjects (579.19±85.06 mg/24 h; P<0.01). In addition, the mean urine calcium level in the P. oleracea group (176.32±27.40 mg/24 h) was significantly lower compared to the control group (194.26±25.17 mg/24 h; P=0.016). Within the groups, analysis revealed that in subjects in P. oleracea and control groups, mean serum triglyceride (TG) decreased after intervention (P=0.01 and P=0.02, respectively), as well as mean urine citrate level (P<0.01, P=0.01, respectively).

Conclusion: The findings show that P. oleracea may be proposed as a medicinal plant that has a preventive effect on kidney stone formation by increasing urine citrate and decreasing urine calcium level.

Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20170725035305N4; https://en.irct.ir/trial/42388, ethical code; IR.SBMU.MSP. REC.1398.538).


Implication for health policy/practice/research/medical education:

Portulaca oleracea is used in traditional medicine as a medicinal plant. According to its various medical properties, potential antioxidant and anti-inflammatory properties, the present study aimed to investigate the efficacy of P. oleracea powder on 24-hour urine indices in patients with nephrolithiasis and normal kidney function. The findings show that P. oleracea did not significantly affect urine creatinine levels. However, it significantly increased urine citrate levels and decreased urine calcium levels, which are common risk factors for nephrolithiasis. Therefore, P. oleracea may be proposed as a medicinal plant that has a preventive effect on kidney stone formation, though more studies are recommended to evaluate its safety and efficacy.

Please cite this paper as: Alirezaei A, Karimi Toudeshki K, Nouri SB, Fazeli SA, Hatami F, Miladipour A, Montazeri-Ghominezhad SP. The effects of Portulaca oleracea extract on 24-hour urine indices in patients with renal stone: A double-blind randomized placebo-controlled clinical trial. J Renal Inj Prev. 2023; 12(4): e32240. doi: 10.34172/jrip.2023.32240.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1493

Your browser does not support the canvas element.


PDF Download: 935

Your browser does not support the canvas element.