Azadeh Yousefnezhad
1 
, Seyedeh Reyhaneh Yousefi Sharemi
2 , Elham Saffarieh
3 , Fahimeh Nokhostin
4* 1 Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Obstetrics and Gynecology, Kurdistan University of Medical Sciences, Sanandaj, Iran
3 Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran
4 Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Sadughi University of Medical Sciences, Yazd, Iran
Abstract
Renal impairment is a common complication in patients with ovarian cancer. Renal impairment in ovarian cancer patients can be caused by various factors. Many of the chemotherapeutic agents administered to treat ovarian cancer are nephrotoxic and can promote kidney dysfunction, leading to renal impairment. Ovarian tumors can obstruct the urinary tract, leading to a reduction in renal function and dilation of the upper urinary tract. Acute kidney injury (AKI) can occur in ovarian cancer patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Women treated for epithelial ovarian cancer suffer an accelerated rate of renal function decline, independent of major risk factors for kidney disease. Conversely, renal impairment can affect the dosage of chemotherapy drugs used in ovarian cancer treatment. Dose reduction, dose adjustment based on pharmacokinetic data, alternative treatment regimens, and individualized dosing may be necessary to ensure optimal therapeutic outcomes while minimizing the risk of toxicity and treatment-related complications.
Implication for health policy/practice/research/medical education:
Renal impairment is a common complication in patients with ovarian cancer. Kidney dysfunction following ovarian cancer can be caused by a variety of factors, including tumor obstruction, chemotherapy toxicity, and dehydration. Patients with ovarian cancer who develop renal impairment may experience symptoms such as fatigue, nausea, vomiting, and swelling in the legs and feet. Treatment options for renal impairment in these patients may include hydration therapy, and medications to manage electrolyte imbalances. In addition to managing the symptoms of renal impairment, it is important to address the underlying cause of the condition. For example, if the impairment is caused by tumor obstruction, surgery or radiation therapy may be necessary to remove or shrink the tumor.
Please cite this paper as: Yousefnezhad A, Yousefi Sharemi SR, Saffarieh E, Nokhostin F. Renal dysfunction in individuals with ovarian cancer; a review on current concepts. J Renal Inj Prev. 2023; 12(4): e32247. doi: 10.34172/jrip.2023.32247.