Amirhesam Alirezaei
1, Elham Zare
2*, Mahmoud Parvin
3, Fatemeh Nili
4, Mahmood Bakhtiyari
5,61 Clinical Research Developement Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of pathology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Pathology, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
6 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Post-transplant glomerular diseases (PTGN) have been documented frequently, although majority of them, are recurrences of primary diseases. In some cases, de novo glomerular diseases can develop in recipients. In this paper, a case of de novo minimal change disease (MCD) after non-related live donor kidney transplantation in a patient with a history of biopsy proven membranous nephropathy is described. A 25-year-old man with history of biopsy-proven idiopathic membranous glomerulopathy (MGN) who had been transplanted 3 weeks before referred to hospital, presented with peripheral edema and massive proteinuria. First kidney biopsy was compatible with acute cellular rejection with glomerulitis. The patient was treated with methylprednisolone. Panel reactive antibody (PRA) and C4d were negative. Anti- phospholipase A2 receptor (PLA2R) antibody was also negative. Another allograft biopsy was conducted and the result was highly suggestive of MCD. Thus final diagnosis was de novo MCD and proteinuria decreased successfully.
Implication for health policy/practice/research/medical education:
De novo minimal change disease after kidney transplantation in a 25 year old patient with history of biopsy proven membranous glomerulopathy (MGN) is described.
Please cite this paper as: Alirezaei AH, Zare E, Parvin M, Nili F, Bakhtiyari M. De novo minimal change disease after kidney transplantation. J Renal Inj Prev. 2018;7(2):103-106. DOI: 10.15171/jrip.2018.24.