Abolfazl Abbaszadeh
1, Sahar Koushki
2, Shirin Koushki
2, Marzieh Eskandarzadeh
2, Amin Hasanvand
3*1 Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract
Metformin, a hypoglycemic drug, increases peripheral glucose uptake, decreases liver glucose
production and suppresses insulin resistance in liver and skeletal muscle. The molecular
anti-inflammatory mechanism of metformin involves the reduction of the level of proinflammatory
cytokines through AMPK activation. It can reduce endothelial dysfunction
by ameliorating the expression of inflammatory gene and protein like vascular cell adhesion
molecule-1 (VCAM-1), and vasodilating maternal vessels. Many studies showed that AMPK
activation were the main contributors to the antioxidant and anti-inflammatory effects of
metformin.
Implication for health policy/practice/research/medical education:
Metformin can improve chronic inflammation and oxidative stress. The main mechanism of AMPK effects was decrease of proinflammatory
cytokines and oxidative stress factors after treatment with metformin in diseases.
Please cite this paper as: Abbaszadeh A, Koushki S, Koushki S, Eskandarzadeh M, Hasanvand A. . Metformin; a mini-review to
its antioxidative and anti-inflammatory properties. J Renal Inj Prev. 2018;7(1):7-10. DOI: 10.15171/jrip.2018.02.