Abstract
Introduction: Up to 10% of lupus nephritis (LN) do not show IgG deposition of
immunofluorescence (IF). Our rationale is to find out whether there is any significant
difference in clinical presentation and histopathological findings in both groups of patients.
Objectives: To compare clinical and histopathological findings in patients with LN having
IgG deposits versus patients without IgG deposits in renal biopsies.
Patients and Methods: Two groups of IgG positive and IgG negative were made and their
details were recorded. Data were analyzed by SPSS 20. Fischer’s exact test was applied to
determine significance of above mentioned clinical and laboratory findings with/without IgG
deposits in renal biopsies.
Results: Fischer’s exact test results’ for all variables was as follows; M: F ratio was 0.5, edema
0.10, deranged RFT 0.3, hematuria 0.10, proteinuria 0.4, anti-double stranded DNA antibody
0.3 and anti-nuclear antibody 0.5. The P values of LN were class II 0.003, class III 0.8 and
class IV 0.3. These findings show that groups with no IgG deposits on IF, present with milder
clinical disease.
Conclusion: There was a marginal significant P value for hematuria, edema and LN class II,
pointing towards the fact that relatively milder disease in IgG negative group as compared to
IgG positive group.