Abstract
Introduction: The salt diet during the pregnancy may disturb the adult offspring’s organs
functions.
Objectives: This study was designed to determine the role of high salt intake during pregnancy
on the outcome of renal ischemia reperfusion (IR) in adult offspring.
Materials and Methods: Renal IR was induced in 55 adult male and female offspring from
mothers who intake high salt or normal drinking water during pregnancy, and the kidney
function was evaluated.
Results: Salt intake during pregnancy increased the serum levels of creatinine (Cr) and blood
urea nitrogen (BUN) and decreased creatinine clearances (ClCr) level in offspring after renal
IR gender dependently.
Conclusion: The structural change in kidney of offspring from mothers who were subjected
to salt intake during pregnancy may influence the outcomes of offspring’s kidney functions
after renal IR.