Abstract
Introduction: Hemodialysis patients usually demonstrate lower immune response to hepatitis
B vaccine compared to non-uremic population.
Objectives: The present study aimed to determine the level of response to hepatitis B
vaccination in patients under hemodialysis.
Patients and Methods: This study was conducted on 172 live patients receiving hemodialysis
in the dialysis department of Buali hospital in Ardabil, Iran (2015). To analyze their response
to the vaccine, their vaccination titers were investigated. Before vaccination, the serological
markers of hepatitis B and C were checked in all of the patients. Those for whom HBsAg and
HBsAb results were negative and had not received the vaccinein the past entered the study.
The patients received a double dose of hepatitis B vaccine at 0, 1, and 6 months after the
beginning of dialysis. The response to the vaccine was investigated by measuring the level of
patients’ hepatitis B antibody one month after receiving the last dose of the vaccine.
Results: Seventy patients (40% of the total) displayed a proper immune response to the
vaccine, 34 patients (19.8%) were without, and 68 patients (39.5%) were identified to have poor
response. The results of Pearson’s correlation test indicated that there is a negative correlation
between the patients’ age and their response to the vaccine.
Conclusion: The results of this study indicated that higher age is one of the factors that reduce
the effectiveness of hepatitis B vaccine in hemodialysis patients.