Asymptomatic Bacteriuria in Type II Diabetics and non Diabetics: Risk factors, Bacterial types and their corresponding resistance pattern

Abstract

 Introduction: Silent Bacteruria or asymptomatic bacteriuria (ASB) means the existence of bacteria in urine without clinical signs or symptoms of the host. Both diabetic and non diabetic patients have the possibility of urinary tract infections with or without symptoms. Bacteria cause asymptomatic bacteriuria are colonizing flora which usually arise from the vagina, gut, or periurethral area. The risk of asymptomatic bacteriuria is greater among diabetic and non-diabetic patients particularly women. Asymptomatic bacteriuria is considered clinically significant and worth treating primarily in pregnant women. Objectives: In this study, we examined the silent bacteriuria among diabetics and healthy persons, type of strains, and their corresponding resistance pattern. Materials and Methods: A total of 220 diabetic patients and 70 healthy persons were subjected to study. Diabetic patients without malignancies, asthma or heart diseases, symptoms free regarding urinary tract infection and without prior antibiotic administration were included. Blood sample obtained from all subjects study under aseptic technique for fasting blood sugar and HbA1C. Urine samples were collected, All urine samples were passed to cultivation on suitable culture media. Plates of more than two clinical isolates from the same patient were considered to be contaminated. Plates showing more than 104 CFUs/ mL were considered significant ASB and subjected for confirmation of bacterial type and antibiotic susceptibility test. Results: From diabetics urine samples, 21(9.55%) and from healthy persons 3(4.3%) showed significant bacterial growth. In both diabetics and non-diabetics, women demonstrated a far higher prevalence of ASB than men. The high the HbA1c, the more possibility of positive ASB. In 66,7% of ASB, E. coli was the main uropathogens, followed by K. pneumoniae. These species showed identical antibiotic resistance patterns. Conclusion: These findings emphasize the importance of routine urine culture and antibiotic sensitivity testing for diabetic patients who have risk factors identified. ASB should be treated in order to avoid potential serious renal complications. Amikacin, Gentamicin, Piperacillin/Tazobactam, Fosfomycin, and Ciprofloxacin are recomended for treatment of ASB while Ampicillin is not.

Keywords: Diabetics, DM, Asymptomatic, Bacteruria, E.coli, Antibiotics