Abstract
Context: To date, several studies have been done regarding the treatment of atypical
hemolytic uremic syndrome (aHUS) which discussed eculizumab as a potential treatment for
this syndrome. However, the safety and efficacy of eculizumab were not fully assessed. This
study aims to do a systematic review about the efficacy and safety of eculizumab in treatment
of aHUS.
Evidence Acquisitions: An electronic literature search was conducted to identify appropriate
studies. We included all randomized trials and observational studies about using eculizumab
in aHUS. Two independent reviewers extracted data from the articles according to the
selection criteria.
Results: Eligible studies were included in this systematic review. The literature search and
reference mining yielded 571 potential relevant articles. We removed 173 articles because
of duplication. We also excluded 245 articles after reviewing the titles and abstracts, and
removed 61 studies because the topics were not relevant to the subject. Finally, five studies
were included in the systematic review.
Conclusions: Acknowledging the limitations of the study due to the size and nature of the
included studies, our systematic review shows that eculizumab was effective in the treatment
of aHUS. However, further large randomized trials are suggested.