Mohamad Ali Dayani
1 
, Ali Hasanpour Dehkordi
2* , Maryam Miraghajani
3,4 1 Department of Radiology, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Social Determinants of Health Research Center.,School of allied medical scinces, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
Abstract
Nitric oxide (NO) has various physiological and biochemical effects. In many biological
systems of the body, NO acts as a messenger molecule via cyclic guanosine monophosphate
(cGMP), which affects the body cells. NO is synthesized in the body from the L-arginine
amino acid by the NO synthases enzyme. This enzyme consists of three major isoforms
including neurotransmitter, endothelial and inductive types. According to the results of
numerous studies, the administration of ozone as a complementary therapy of the diseases
is a less complicated and cost-effective way. Over the past forty years, the results of ozone
therapy have been satisfactory and without any problems. Ozone therapy affects various
diseases. For example, in treatment for vascular diseases and some degenerative diseases, it
has an ameliorative impact. Regarding kidney disease, still many experimental or clinical
studies are necessary to find its improvement/anti-oxidative effect.
Implication for health policy/practice/research/medical education:
Ozone therapy in treatment of various diseases such as vascular diseases and diabetic foot has an ameliorative impact. Regarding
kidney disease, still many experimental or clinical studies are necessary to find its improvement/anti-oxidative effect.
Please cite this paper as: Dayani MA, Hasanpour Dehkordi A, Miraghajani M. Ozone therapy in chronic diseases; a narrative
review of the literature. J Renal Inj Prev. 2019; 8(3): x-x. DOI: 10.15171/jrip.2019.xx