Abstract
Introduction: Urinary stones are one of the most common and painful diseases of humans
after urinary tract infections and prostate diseases.
Objectives: The aim of this study was comparing the efficacy and complications of combined
cystone and hydrochlorothiazide with cystone monotherapy in the treatment of upper
urinary stones.
Patients and Methods: In this randomized clinical trial 80 patients older than 15 years
old with renal and ureteral stones less than 10 mm after taking informed consent form
were allocated randomly in one of two groups. Patients with azotemia, hydronephrosis,
bothersome pain and pregnant women were excluded. In the first group, combinations of
cystone and hydrochlorothiazide tablets (every 12 hours, two 100 mg cystone and 25 mg
hydrochlorothiazide) were prescribed. In the second group, cystone were prescribed as the
first group. One month later, patients were followed by kidney, ureter, and bladder x-ray
(KUB) and ultrasonography and the success of treatment was determined by changing the
size of stones and report of stone passage by the patients. All data were collected and analyzed
by SPSS software version 23 and statistical tests.
Results: The mean age of the patients in combined and single groups were 48.02±13.72 and
44.15 ± 14.86(P = 0.24) years respectively. The mean size of stone after treatment in two groups
was 1.72±0.98 and 1.85±0.78 mm respectively (P=0.53). Regarding efficacy of combined and
single group, more than 90% of the patients reported stones passage after the intervention
(P=0.06). There were no significant differences in mean blood urea (P=0.38) and serum
creatinine (P=0.53) after treatment in two groups.
Conclusion: The results of this study showed that combination of cystone and
hydrochlorothiazide do not increase the efficacy of cystone in treatment and passage of
urinary stones, although in both groups stone passage significantly increased.