Abstract
Introduction: Contrast-induced nephropathy (CIN) is a cause of acute renal failure (RF) that canlead to certain complications such as chronic RF. Acute and chronic RF may need to dialysis andthe need for dialysis, elongates hospital stay, increases costs, and finally increases mortality rate.Currently, the use of different antioxidants to prevent nephrotoxicity is the main focus of manystudies in this field. Curcumin (CUR) is one of these compounds as the main isolated compoundfrom the essential oil of turmeric underground stem. CUR has numerous pharmaceuticalproperties such as antioxidant, anticancer, and antimicrobial.
Objectives: The aim of this study was to investigate the effect of various doses of CUR onbiochemical and histopathological parameters in CIN.Materials and Methods: To conduct this study, 36 Wistar rats were divided into six groups of 6each; negative control (NC) did not receive any drugs. Positive control (PC) was intraperitoneallyinjected with 10 ml/kg contrast media. CUR 50 and 250 mg/kg/d (CUR50, CUR250) groups werereceived intraperitoneally CUR suspended in corn oil for 10 days. CUR 50 or CUR 250 plus contrastmedia (CUR50 + CM, CUR250 + CM) groups were received intraperitoneally CUR + CM with 10mL/kg/d of contrast media and CUR suspension for 10 days.
Results: The results showed that CUR caused a significant decrease in serum creatinine (Cr),blood urea nitrogen (BUN), and the percentage of debris, vacuolization, dilatation and renal tissuedegeneration of renal tubules (P < 0.05).
Conclusion: We found the positive impact of CUR to protect kidney against the adverse effectsof contrast media. Hence this compound might be useful against contrast induced acute kidneyinjury in patients at risk of contrast media induced nephrotoxicity.