Rahimeh Eskandarian
1, Soheila Jafari
1, Majid Mir Mohammadkhani
2, Maliheh Yarmohamadi
1*, Zahra Alizadeh Sani
3,4, Mohaddeseh Behjati
3, Roohallah Alizadehsani
5, Sheikh Mohammed Shariful Islam
6,7,81 Clinical Research Development Unit, Kowsar Educational, Research and Therapeutic Hospital, Semnan University of Medical Sciences, Semnan, Iran
2 Social Determinants of Health Research Center, Department of Epidemiology and Biostatistics, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
4 Omid hospital, Iran University of Medical Sciences,Tehran, Iran
5 Institute for Intelligent Systems Research and Innovation, Deakin University, Geelong, VIC 3216, Australia
6 Institute for Physical Activity and Nutrition, Deakin University, Melbourne, Australia
7 Cardiovascular Division, The George Institute for Global Health, Australia
8 Sydney Medical School, University of Sydney, Australia
Abstract
Introduction: Pulmonary hypertension is a progressive and severe disease associated with left or right ventricular dysfunction and is common in patients under hemodialysis. One of the factors in its development is parathormone but this relationship is unclear.
Objectives: In this study, the difference between serum levels of parathyroid hormone (PTH) in hemodialysis patients with and without pulmonary artery hypertension (PAH) was investigated.
Patients and Methods: We conducted a cross-sectional study among hemodialysis patients referred to a tertiary hospital in Iran. Characteristics of coronary artery and pulmonary arteries were recorded by echocardiography. The laboratory data were measured and recorded. Statistical analysis was performed at 95% confidence level and with a significance level of less than 5%.
Results: Of 65 enrolled patients, 41 had normal pulmonary artery pressure, and 24 had pulmonary hypertension. The mean age in patients with and without pulmonary hypertension was significantly different (P=0.010). There was no significant difference in serum PTH levels between patients with and without pulmonary hypertension (P=0.496). The mean serum levels of calcium, albumin, triglyceride, and cholesterol in two groups of patients with and without pulmonary hypertension was not significantly different (P=0.906).
Conclusion: In our study, no significant correlation between pulmonary hypertension and PTH was detected. The prevalence of pulmonary arterial hypertension in our study was relatively high, suggesting the need to pay attention to pulmonary hypertension in hemodialysis patients
Keywords: Pulmonary hypertension, Hemodialysis, Parathormone