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Submitted: 01 Aug 2021
Accepted: 20 Nov 2021
ePublished: 06 Dec 2021
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J Renal Inj Prev. 2022;11(2): e31942.
doi: 10.34172/jrip.2022.31942

Scopus ID: 85130320781
  Abstract View: 1719
  PDF Download: 935

Short Communication

Effect of hypericum perforatum tea on renal histology and function

Adil A. Mustafa 1 ORCID logo, Moamin J. Salim 2, Khalaf N. Ahmad 1, Mohammed F. Ahmed 2, Azzawi M. Hadi 2* ORCID logo

1 Department of Food Sciences, Tikrit University, College Agriculture, Tikrit, Iraq
2 Department of Surgery, University of Ninevah, College of Medicne, Mosul, Iraq
*Corresponding Author: *Corresponding authors: Azzawi M. Hadi, Email: , Email: azzawihadi@gmail.com

Abstract

Introduction: Hypericum perforatum consists of several biologically active compounds that may affect cell physiology.

Objectives: This study attempted to estimate the effect and safety of a tea that was prepared from H. perforatum on renal histology and function.

Materials and Methods: A double-blind controlled experimental trial was conducted on 25 male rats. These animals were divided into four groups. Three of them were labeled as the study groups, and each consisted of seven animals. The fourth group was labeled as the control group consisting of four animals that lived in the same environment and consumed the same food as the other groups. The animals in each study group consumed a prepared tea with a different concentration for each group. The herbal tea of H. perforatum was made as recommended by the local traditional preparation method. Doses of 3, 6, and 9 cc/kg/d were calculated and selected according to the recommendation. Each of these doses was given to each group of the experiment for four weeks mixed with water.

Results: A slight increase in blood urea and serum creatinine and a decrease in serum albumin levels were noticed in the experimental groups compared to the control group. In addition, the weight of the kidneys in the study groups was more than the control group. There were microscopical changes in the renal histology that was noticed in the higher doses of H. perforatum tea.

Conclusion: Higher doses of H. perforatum tea can induce damage to the renal tissue.



Implication for health policy/practice/research/medical education:

In a double-blind controlled experimental trial was conducted on male rats, we found, high doses of hypericum perforatum tea may lead to adverse effects on renal function and histology; however, it could be beneficial at low and moderate doses.

Please cite this paper as: Mustafa AA, Salim, MJ, Ahmad KN, Ahmed MF, Hadi AM. Effect of hypericum perforatum tea on renal histology and function. J Renal Inj Prev. 2022; 11(2): 31942. doi: 10.34172/jrip.2022.31942.

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